Abstract: Based on the idea of development with science and the analysis about the characteristics of the constructional and operational environment and the layout of productivity of Qinghai-Tibet railway,the paper puts forward the necessity, the basic assumption and the general idea of setting up an integrative management system of environment-health-safety-transportation in the Qinghai-Tibet railway. It also systematically explains the approach to realizing the integrative management system,which includes the research on the environmental aspects and the rule of disaster generation and the social environment and transport demands of the area along the line, the entironment protection, the establishment of the inspecting environment and indicating disaster system, the enhancement of the railway employees’ labor insurance and the prevention and cure of their occupational disease etc.On the basis of the research and practice of the integrative management system,it aims to exert the commonweal of railway and build up and manage the top ranking plateau railway.

Key words: Qinghai-Tibet railway, transportation operation, integrative management system of environment-health-safety-transportation