The manufacturing of advanced, complex products, such as atomic bombs and artificial satellites, as well as highly integrated technological projects like lunar landings and rocket recovery, constitutes a highly complex, systemic process. In order to support the disruptive innovation and development of such system engineering as high-end complex product manufacturing, the basic concept of technology strategic supply chain is proposed.A thorough examination of the formation and development of this supply chain can address key scientific questions, such as how high-end complex products are created and evolve, the underlying drivers of this process, and the fundamental principles governing them, thereby facilitating the original creation and innovative development of these products. The complex systemic processes involved in the manufacturing of high-end complex products is first reviewed. Then, the concept of the technology strategic supply chain is defined based on the supply-demand relationship among science, technology, engineering, and industry. Based on an analysis of the typical characteristics of the evolution of technology strategic supply chains, the following four major scientific issues about technology strategic supply chains are explored: the formation mechanism and dynamic evolution, factor space and collaborative optimization, resilience design and risk management, and operational mechanisms and efficiency enhancement. Finally, strategic insights is offered for constructing technology strategic supply chains, focusing on innovation talent, innovation ecosystems, cutting-edge technologies, leading enterprises, and management mechanisms, with the goal of advancing China’s technology strategic supply chain and contributing to the high-quality development of China’s science, technology, and economy.